Age-Dependent DNA Methylation Variability on the X-Chromosome in Male and Female Twins.

Epigenomes · 2024 · PMC11586961 · PMID 39584966

Europe PMC DOI

hedged sentences

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closest p · 1.0× alpha

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boldest claim

The sentences

nominally significantp < 0.05actually significant

In females, we found a significantly higher proportion of CpGs showing increased variability with age among nominally significant ( p < 0.05) CpGs under inactivation, but not among CpGs escaping inactivation.

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a slight trendno p-value reported

Survival analysis showed a slight trend of correlation by directional change in the variable CpGs with mortality in males.

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