The radioligand binding assay results showed a clear trend for the 5-HT 7 R-preferable configurations, i.e., the combination of 5 S /7 R as the most profitable in terms of the 5-HT 7 R affinity for stereoisomers of both analogues ( 1 and 2 ).
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The Importance of Stereochemistry in 5-HT<sub>7</sub>R Modulation─A Case Study of Hydantoin Derivatives.
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