did not reach statistical significancep = 0.0558
The mean annualized rate of exacerbation-related ED visits decreased by four-fifths after eculizumab initiation, from 0.054 PPPY before eculizumab initiation to 0.012 PPPY during eculizumab treatment; however, the difference did not reach statistical significance ( p = 0.0558; Fig. 1 a).