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Haploinsufficiency at the CX3CR1 locus of hematopoietic stem cells favors the appearance of microglia-like cells in the central nervous system of transplant recipients.

Nat Commun · 2024 · PMC11589136 · PMID 39587072

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Likely because of the limitations of the chimeric model, differences in CNS engraftment of the CX3CR1 edited versus control cells did not reach statistical significance.

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