Epigenetic mechanisms mediate cytochrome P450 1A1 expression and lung endothelial injury caused by MRSA in vitro and in vivo.

Moreover, rhapontigenin decreased MRSA‐induced IL‐6 release by ~25% compared to vehicle, although this effect did not reach statistical significance (Figure 5G ). 3.6 Rhapontigenin attenuates MRSA ‐induced lung injury in mice To determine the functional role of CYP1A1 in vivo, we employed our previously established mouse model of ALI caused by live MRSA. 19 , 20 One hour prior to intratracheal administration of MRSA, animals received either vehicle or the CYP1A1 inhibitor rhapontigenin at 10 mg/kg (IP).

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