Comparative Safety Profiles and Usage Patterns of Iodinated Contrast Media in Medical Imaging.

Quarterly Trends in HSR Incidence We observed a trend towards higher HSR rates in the first quarter of each year, decreasing towards the fourth quarter, although this did not reach statistical significance ( p = 0.9471) ( Table 4 , Figure 4 A).

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When quarterly variation was analyzed separately for first- and second-line agents, the HSR rates for second-line agents showed a decreasing trend from the first to the fourth quarter, which was more pronounced than that for first-line agents, although this was not statistically significant ( Table 6 , Figure 4 B).

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