Sex-Specific Changes in Cardiac Function and Electrophysiology During Progression of Adenine-Induced Chronic Kidney Disease in Mice.

We also observed a decrease in cardiac output in Adenine-treated males compared to Control males at all time points, with near significance ( p < 0.07) across all weeks ( Figure 6 C).

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Mitral valve early flow velocity (MV E) decreased in Adenine males, with a significant difference observed at week 6 and a trend toward significance at weeks 9 and 12 ( Figure 5 B).

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Of all the parameters identified, S peak –J duration was the only one that showed a trend throughout disease progression, with significant differences between regimen type and sex ( Figure 7 E).

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