Direct Oral Anticoagulants Versus Aspirin for Stroke Prevention After Embolic Stroke of Undetermined Source: An Updated Meta-Analysis of Randomized Controlled Trials.

The test for subgroup differences approached significance ( p interaction = 0.05, Cochran’s Q test: p = 0.05; I 2 = 67.7%), suggesting a potential age-dependent efficacy of DOACs compared to aspirin in preventing any recurrent stroke after an ESUS.

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