Initial Exploration of the In Vitro Activation of GLP-1 and GIP Receptors and Pancreatic Islet Cell Protection by Salmon-Derived Bioactive Peptides.

Mar Drugs · 2024 · PMC11595994 · PMID 39590770

Europe PMC DOI

hedged sentences

0.0520

closest p · 1.0× alpha

0.0580

boldest claim

The sentences

a near-significant trendp = 0.052so close (0.05 < p ≤ 0.1)

The 10 mg/mL dose of SPH resulted in a significant increase in GLP-1 receptor activity ( p < 0.05), and the 1 mg/mL showed a near-significant trend ( p = 0.052).

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did not quite reach significancep = 0.058so close (0.05 < p ≤ 0.1)

These peptides, at a dilution of 1 mg/mL, showed a normalized mean increase of 1.87-fold in GLP-1 receptor activity which reached statistical significance versus the PBS control ( p < 0.05), compared to a mean increase of 1.53-fold with SPH dosed at 10 mg/mL (which did not quite reach significance versus control, p = 0.058).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.