β2-Chimaerin, a GTPase-Activating Protein for Rac1, Is a Novel Regulator of Hepatic Insulin Signaling and Glucose Metabolism.

Glucose levels of β2-KO mice were significantly lower at 15 and 30 min after insulin injection compared to WT littermates ( Figure 2 d), with differences in the AUC showing a trend towards significance ( p -value = 0.08) ( Figure 2 e).

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We examined AKT-mediated phosphorylation of these proteins and found that β2-KO livers exhibited enhanced phosphorylation of both GSK3β and FOXO1 compared to WTs ( Figure 4 c,d), although differences did not reach statistical significance ( p - values of 0.33 and 0.41, respectively).

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