Effects of 5-ion 6-beam sequential irradiation in the presence and absence of hindlimb or control hindlimb unloading on behavioral performances and plasma metabolic pathways of Fischer 344 rats.

When the percentage of animals that explored the objects on day 4 was examined, the animals under HU showed a trend toward a lower percentage (27%) than animals without HU (48%) ( z (1, 3.805) = 1.951, p = 0.051, two-sided chi-squared test) or animals under the control HU condition (50%) ( z (1, 3.732) = 1.932, p = 0.053, two-sided chi-squared test). 3.3 Plasma metabolomics analysis When the effects of radiation were analyzed in the plasma of animals without HU or control HU, the riboflavin metabolic pathway was affected most along with glycerophospholipid, sphingolipid, and glutathione metabolic pathways being less affected in the comparison of sham irradiation vs. 0.75 Gy ( Figure 4A ).

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