Differences in Cytokine Expression at Baseline and in Response to Mineral Stimulation by Peripheral Blood Mononuclear Cells from Podoconiosis Cases and Healthy Control Individuals.

Averting the persistence of TNF-α -associated inflammation and restoring immune regulation has been the main target of biological therapies, whereby TNF-α blockade using monoclonal antibodies has been widely used to treat autoimmune diseases such as rheumatoid arthritis [ 18 , 19 ] and ulcerative colitis [ 20 ], and this could potentially be useful in reducing inflammation in podoconiosis, though a lot more research is required before reaching this step as the increase in TNF-α - in the patients is only moderately significant.

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