PNPO-PLP axis senses prolonged hypoxia in macrophages by regulating lysosomal activity.

Among the inflammatory cytokine genes examined, Il6 was upregulated in hypoxia regardless of the duration compared to normoxia and Tnfa was upregulated only in prolonged hypoxia, although the difference did not reach statistical significance in male mice (Fig. 8e and Extended Data Fig. 10a ).

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