It was worth noting that although the protein expression of HO-1 increased with the increase of lycorine concentration, the protein expression of p62, keap1, and nrf2 showed a trend of first decreasing and then increasing, while the protein expression of NQO1 showed a trend of first increasing and then decreasing (Fig. 6 C).
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Lycorine ameliorates liver steatosis, oxidative stress, ferroptosis and intestinal homeostasis imbalance in MASLD mice.
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