Coffee consumption is associated with intestinal Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts.

By contrast, the highest median fold change between moderate and high drinkers was only 1.4 and did not reach statistical significance in three out of five cohorts (Fig. 3a and Supplementary Table 14 ).

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We identified 150 correlations, which remained highly significant after controlling for the decaffeinated coffee intake ( q < 0.001, n participants = 12,089; Extended Data Fig. 4c and Supplementary Table 8 ).

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