Zika virus encephalitis causes transient reduction of functional cortical connectivity.

Colocalization of synapsin and PSD95 also showed a trend toward decrease in mice during acute infection compared with mock-infected controls [ Fig. 6(e) ], suggesting an association between synapsin+PSD-95+ synapses and interhemispheric connectivity during acute ZIKV infection.

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When we compared FC in both mock- and ZIKV-MA-infected mice at 7 dpi and 42 dpi, we also noted that mock-infected mice had an overall trend toward decreased FC from 7 to 42 dpi, indicating a possible age-related change in FC (Fig.

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