Renal pressure-flow relationship and renin activation in a porcine model comparing unilateral and bilateral renal artery stenosis.

Although not statistically significant, a clear trend towards more pronounced renin activation was observed in the presence of contralateral RAS (Figure 7 ). 4 DISCUSSION In an animal model of unilateral graded RAS in the presence of a significant contralateral stenosis, a 25% decrease in perfusion pressure results in a significant decrease in distal renal flow, causing a more pronounced upregulation of renin secretion when compared to a model of graded unilateral RAS without significant contralateral stenosis.

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