Impact of soluble epoxide hydrolase inhibition on silica-induced pulmonary fibrosis, ectopic lymphoid neogenesis, and autoantibody production in lupus-prone mice.

Overall, mice fed TPPU trended toward less cSiO 2 -induced fibrosis and CD206 + macrophage/monocyte and Ly6B.2 + neutrophil infiltration but these differences did not reach statistical significance ( Figures 7 – 9 ). cSiO 2 -induced ELS development and AAb production in not affected by TPPU Conspicuous accumulation of CD3 + and CD45R + lymphoid cells, indicative of T and B cells, respectively, and elevated ELS scores in perivascular and peribronchiolar interstitial tissue were evident in the lungs of cSiO 2 -treated mice after 28 days PI ( Figures 10 ( A – D )).

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