An integrated single-cell atlas of blood immune cells in aging.

The reduction was statistically significant in five datasets ( GSE213516 , GSE214546 , HRA000203, HRA000624, and syn22255433; p < 0.05) and also present in GSE157007 dataset and HRA003766, although the difference in the latter did not reach statistical significance ( p = 0.089).

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Non-classical monocytes were more prevalent in old donors compared to young samples in all datasets, although the effect was borderline significant in all datasets except HRA000624, where it reached statistical significance (Fig.

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