Sodium butyrate prevents cytokine-induced β-cell dysfunction through restoration of stromal interaction molecule 1 expression and activation of store-operated calcium entry.

NaB treatment also showed a trend ( p = 0.0788) to increase AKT phosphorylation in cytokines‐stressed mouse islets (Figure 7 ). 4 DISCUSSION NaB is a simple four‐carbon SCFA 40 that has been shown to have beneficial effects on pancreatic β‐cell function in mouse islets, INS‐1E cells, and human EndoC‐βH1 cells. 17 At present, the mechanisms underlying these effects have not been fully elucidated.

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