Cardiovascular disease in pregnancy: Prevalence and obstetric outcomes in a Swedish population-based cohort study between 2000 and 2019.

1 Although CVD are among the leading causes of maternal mortality, with an increasing trend in western industrialized countries, there are limited data on the prevalence of these disorders in Sweden and globally. 2 , 3 Meanwhile, during recent decades, the mean age of women at first birth has increased along with the mean age at childbirth in most high‐ and middle‐income countries. 4 Women, thus, have more accumulated time to develop acquired CVD before they become pregnant.

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Joinpoint regression, which divides data into subsets with a unique linear trend (where the lines are connected at the joinpoints), was used to assess temporal changes in the prevalence of overall CVD, where the Monte Carlo Permutation method was used to test for a significant trend. 17 The joinpoint analyses indicated a random pattern for CVD subtypes with no joinpoints identified.

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Therefore, an overall trend test, Cochran‐Armitage two‐sided test, was used to assess significant changes in the prevalence of subtypes of CVD over time.

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