The effect of sulthiame on potential biomarkers in moderate to severe obstructive sleep apnoea.

In pairwise comparisons, HIF-1α concentration was significantly reduced during STM treatment in the 400 mg group (median difference −4% (95% CI −8– −2%); p<0.001 versus placebo) whereas the difference to placebo did not reach statistical significance in the 200 mg group ( figure 2b ).

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