Neutrophil extracellular traps are associated with airways inflammation and increased severity of lung disease in cystic fibrosis.

The level of NETs in sputum was no different in people either taking or not taking the long-term antibiotic azithromycin ( figure 3b ) but were reduced in those taking DNase ( figure 3c ), correspondingly the level of IL-8 was also reduced in the sputum of these individuals, but this did not reach statistical significance ( supplementary figure 1a ). 13 subjects were also taking hypertonic saline (HTS) as a mucolytic treatment, and this had no significant impact on sputum NETs level ( supplementary table 1 and supplementary figure 1b ).

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