Loss of USP10 promotes hepatocellular carcinoma proliferation by regulating the serine synthesis pathway through inhibition of LKB1 activity.

Tumor tissues from USP10 KO mice and the WT group were selected, and qRT‐PCR (Figure 5E ) and western blot (Figure 5F ) analyses revealed that ATF4, PHGDH, PSAT1, and PSPH showed a trend of increase after USP10 KO.

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