Interpretable survival network for progression risk analysis of multimodality imaging biomarkers in poor-prognosis head and neck cancers.

Although the interaction of p16 status with MTV 50 of FDG or mean BV in primary HNCs has not been reported before, the interaction between p16 status and ADC metrics has been explored and showed a trend of high mean ADC values in p16- tumors compared to p16 + tumors 29 , 40 , 41 , which is consistent with the non-linear interaction between these two features found in the Survnet model.

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