Reduced oxycodone brain delivery in rats due to lipopolysaccharide-induced inflammation: microdialysis insights into brain disposition and sex-specific pharmacokinetics.

Fluids Barriers CNS · 2024 · PMC11613587 · PMID 39623471

Europe PMC DOI

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0.1200

closest p · 2.4× alpha

0.1200

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did not reach statistical significancep = 0.12not close (p > 0.1)

Although a reduced extent of oxycodone uptake was observed in brain ISF, this reduction did not reach statistical significance in the CSF compartments, as indicated by similar K p,uu,LV (p = 0.12) and K p,uu,CM (p = 0.78) after LPS treatment.

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