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Co-infusion of mesenchymal stromal cells to prevent GVHD after allogeneic hematopoietic cell transplantation from HLA-mismatched unrelated donors after reduced-intensity conditioning: a double-blind randomized study and literature review.

Stem Cell Res Ther · 2024 · PMC11613890 · PMID 39627816

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There was a trend for a reduced cumulative incidence of grade II-IV aGVHD with MSC compared to placebo (30% vs 53%) but this did not reach statistical significance, neither in raw proportions nor in cumulative incidences, considering all grades or only grades II-IV aGVHD (Table 2 ).

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