E-52862-A selective sigma-1 receptor antagonist, in peripheral neuropathic pain: Two randomized, double-blind, phase 2 studies in patients with chronic postsurgical pain and painful diabetic neuropathy.

E‐52862 appeared to improve pain scores regardless of baseline pain intensity (2.4‐point reduction from baseline pain scores at Week 4 in patients with severe baseline pain), prior neuropathic pain treatment, or time since surgery, but these observations did not reach statistical significance.

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