ELISL: early-late integrated synthetic lethality prediction in cancer.

Our analysis of TCGA tumour samples unveiled that patients with alterations in a BRCA gene ( BRCA1/2 ) and a member of the NEIL family ( NEIL1-3 ) experienced 24-month longer median survival times than others, although this difference did not reach statistical significance, likely due to the infrequency of co-occurring alterations ( P ≈ 9.63 × 10 − 2 ; Fig. 4f and Supplementary Table S7 ).

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