Interestingly, depletion of Ly6G + cells, while not statistically significant, also showed a trend towards decreasing anti-tumor efficacy, suggesting that Ly6G + myeloid cells could play a supporting role in the observed anti-tumor efficacy of the combination therapy.
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Inhibition of the chemokine receptors CXCR1 and CXCR2 synergizes with docetaxel for effective tumor control and remodeling of the immune microenvironment of HPV-negative head and neck cancer models.
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