H5 subtype avian influenza virus induces Golgi apparatus stress response via TFE3 pathway to promote virus replication.

However, GM130 protein levels displayed a decreasing trend with prolonged infection duration and increasing AIV doses (Figs 2C and 2D , and S4A and S4B ).

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While HSP47 overexpression exhibited an increasing trend in NP expression and viral titers post-AIV infection, the differences did not reach statistical significance ( Fig 3B and 3E ).

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