Suppression of Hippocampal Neurogenesis and Oligodendrocyte Maturation Similar to Developmental Hypothyroidism by Maternal Exposure of Rats to Ammonium Perchlorate, a Gunpowder Raw Material and Known Environmental Contaminant.

In contrast, AP exposure did not alter numbers of OLIG2 + OL lineage cells and showed a trend for increase in numbers of NG2 + OPCs at this time point.

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In this study, immunohistochemical investigation of granule cell lineage markers in offspring on weaning revealed decreased numbers of GFAP + cells and a decreasing trend for numbers of SOX2 + cells with AP at 1000 ppm, as well as decreased numbers of PCNA + proliferating SGZ cells at ≥300 ppm (Table S12 ).

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