Selective Recruitment of a Synthetic Histone Acetyltransferase Can Boost CHO Cell Productivity.

Consistent with this, we found a highly significant ( p < 0.01) increase in DNA methylation at the CMV promoter in a CHO‐K1 clone that underwent transgene silencing during 10 weeks of continuous culture without selection (Figure 3A ).

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Combining these epigenetic regulators raised mAb mRNA levels still further, but the synergism did not reach statistical significance.

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