Additionally, a clear trend towards decreased levels of mRNA transcripts for Tnfα and Il6, and significant downregulation in Il1α and Il8 was found in Cdkn1a -/- mice, fed a DuAL diet ( Fig. 5 F–I).
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Loss of <i>Cdkn1a</i> protects against MASLD alone or with alcohol intake by preserving lipid homeostasis.
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