Tissue-resident natural killer cells support survival in pancreatic cancer through promotion of cDC1-CD8 T activity.

To support this hypothesis, we explored the correlation between trNK and CD8 T infiltration in our murine orthotopic tumor model and found a highly significant positive association (R2=0.6571, p=0.003), which was strengthened when we focused on untreated (Mock) vs IR+IT combinations where trNK cells are evident (R2=0.9223, p=0.0004) ( Figure 6F ).

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Mice in the CCR5i-treated group showed a trend toward reduction in NK cells and all T-cell subsets with a significant reduction in Treg (Live/CD45 + CD3 + CD4 + FOXP3 + ) infiltration, indicating the active recruitment of CCR5 + Tregs in PDAC ( Figure 2B ).

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