Saturation transfer (CEST and MT) MRI for characterization of U-87 MG glioma in the rat.

The differences for the 2‐μT‐saturation, aliphatic‐weighted MTR (MTR −3.6 ppm, 2 μT : 56.1 ± 3.8 vs 60.6 ± 1.1% at 3–5 days, 52.2 ± 4.1 vs 60.2 ± 0.7% at 7–9 days, and 55.0 ± 4.2 vs 59.8 ± 1.2% at 11–13 days), and amide and aliphatic AREX (AREX 3.6 ppm, 2 μT : 0.23 ± 0.04 vs 0.28 ± 0.04 s −1 at 3–5 days, 0.21 ± 0.03 vs 0.29 ± 0.02 s −1 at 7–9 days, and 0.21 ± 0.04 vs 0.30 ± 0.03 s −1 at 11–13 days and AREX −3.6 ppm, 2 μT : 0.20 ± 0.06 vs 0.27 ± 0.05 s −1 at 3–5 days, 0.16 ± 0.06 vs 0.27 ± 0.02 s −1 at 7–9 days, and 0.19 ± 0.06 vs 0.27 ± 0.04 s −1 at 11–13 days) images were weakly significant ( p < 0.05) at 3–5 days after implantation and strongly significant ( p < 0.001) at 7–9 and 11–13 days.

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