Inflammatory bowel disease associated with primary sclerosing cholangitis is associated with an altered gut microbiome and bile acid profile.

A consistent direction of effect, indicating diminished alpha diversity in the IBD-PSC group, was also observed utilizing other indices such as the Chao1 index [ p = 0.057] and Shannon index [ p = 0.12], but these differences did not reach statistical significance [ Supplementary Figure 1 ].

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