Loss of MTAP expression is strongly linked to homozygous 9p21 deletion, unfavorable tumor phenotype, and noninflamed microenvironment in urothelial bladder cancer.

The 9p21 deletions were associated with poor OS in pT2–4 cancer patients ( p = 0.0461; Figure 2A ; p = 0.0182 for the subset of 341 patients who had never been treated with CPIs; supplementary material, Figure S1B ), but the difference in survival did not reach statistical significance when cases with homozygous and heterozygous 9p21 deletion were separately assessed (Figure 2C ).

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