Plakin Expression in Serous Epithelial Ovarian Cancer Has the Potential to Impede Metastatic Spread and Epithelial-Mesenchymal Transition: A Comparative Expression Analysis of Immunohistochemical and In Silico Datasets.

In short, a decreasing trend of VIM was noted in higher grades, stages, and Types compared with lower-rated tumours.

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Although there was insufficient data to establish statistical significance, a clear trend of beneficial high PLEC expression can be seen in Figure 19 . 4.

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Contrary to that, the expression of VIM decreased in different stages and grades of ovarian tumours compared to normal ovaries ( Figure 14 a,b), compared to IHC data in our in-house samples, which showed an increasing trend in different stages and grades of tumours compared to benign ovaries ( Figure 5 c). 3.5.

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Similarly, a small number of high-VIM cases fell into the grade 1 Silverberg–Shimizu group, with a possible trend towards lower expression in grades 2 and 3, but the differences are not strong enough for significance.

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