Clinical Relevance of <i>TP53</i> Mutation and Its Characteristics in Breast Cancer with Long-Term Follow-Up Date.

For instance, an analysis of the METABRIC cohort found that tumors harboring missense mutations in DNA-binding motifs (DBM) had a higher risk of breast cancer-specific mortality compared to tumors with non-missense mutations or missense mutations outside the DBM, though this difference did not reach statistical significance [ 64 ].

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