did not reach statistical significancep -value > 0.05
However, the difference in the biomarker level between NB and CB at T 1 did not reach statistical significance ( p -value > 0.05, CB1 vs.
However, the difference in the biomarker level between NB and CB at T 1 did not reach statistical significance ( p -value > 0.05, CB1 vs.
Moreover, global reports demonstrated an increasing trend in the number of new melanoma cases and deaths [ 2 , 3 ].