PTPRJ is a negative regulator of insulin signaling in neuronal cells, impacting protein biosynthesis, and neurite outgrowth.

In Ptprj KO cells, the ERK1/2 phosphorylation sites T202 and Y204 were significantly increased after 5 min, showed a trend toward elevated phosphorylation after 10, 20, and 30 min (Figure 1J,K ) and an increase in phosphorylation ( p = .0234) when quantifying the entire period (Figure 1L ).

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