Circadian clock disruption impairs immune oscillation in chronic endogenous hypercortisolism: a multi-level analysis from a multicentre clinical trial.

EBioMedicine · 2024 · PMC11647478 · PMID 39612654

Europe PMC DOI

hedged sentence

0.0620

closest p · 1.2× alpha

0.0620

boldest claim

The sentences

approached significancep = 0.062so close (0.05 < p ≤ 0.1)

Results largely overlapped, showing 11 genes with a consistent circadian rhythm ( AANAT, CSNK1A1, CREB1, CREB3, MAT2A, PER1, PER2, PER3, PRKAR2A, TIMELESS and WEE1 ) and two that approached significance ( CLOCK , p = 0.062 [cosinor analysis]; CAMK2D p = 0.061 [cosinor analysis]).

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