Despite a clear functional overlap, the individual transcriptional changes differed, with only a subset (20%–30%) exhibiting nominally significant changes with both ASOs, which could reflect off-target effects or donor-specific differences.
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Long Noncoding RNA TRIBAL Links the 8q24.13 Locus to Hepatic Lipid Metabolism and Coronary Artery Disease.
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Several highly significant processes, consistent with those previously identified, were mapped to 20 clusters based on terms relatedness ( Table S5 ).