An investigation demonstrated that after 48 weeks of sodium pyruvate treatment in patients with mitochondrial disease, blood lactate concentration and lateral ventricular lactate levels significantly declined from baseline, showing a clear trend of improvement in the Newcastle Mitochondrial Disease Adult Scale (NMDAS) partial scores ( 22 ).
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Long-term prognostic factors and outcomes in mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes: a clinical and biochemical marker analysis.
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