Interestingly, the mRNA levels of Dnmt1 and Dnmt3a were increased in the offspring livers from HFD-fed dams, while Dnmt3b only showed a trend of increase whereas the expression of Tet1 , Tet2 , and Tet3 remained unaffected (Fig. 4 A).
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Maternal high-fat diet orchestrates offspring hepatic cholesterol metabolism via MEF2A hypermethylation-mediated CYP7A1 suppression.
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