In rodent liver, TLC–S affects mitochondrial activity and ATPase function, leading to altered ionic homeostasis, which may be significant for understanding the role of bile acids in liver pathology and colorectal cancer.
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The impact of 3-sulfo-taurolithocholic acid on ATPase activity in patients' colorectal cancer and normal colon tissues, and its hepatic effects in rodents.
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TLC–S had no significant effect on Ca 2+ ATPase activity in healthy colon mucosa but showed a trend toward decreased activity in cancer tissue.