Extracellular vesicles from mesenchymal stem cells improve neuroinflammation and neurotransmission in hippocampus and cognitive impairment in rats with mild liver damage and minimal hepatic encephalopathy.

Post hoc analysis with Fisher's LSD test showed that rats with mild liver damage show increased content of IL-1β in glia (189 ± 17% of control rats, p = 0.0087) and C-EVs treatment tended to normalize IL-1β content in glia, but the reduction did not reach statistical significance (148 ± 16%, p = 0.15).

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