CD2AP deficiency aggravates Alzheimer's disease phenotypes and pathology through p38 MAPK activation.

Immunoblot analysis revealed a decreasing trend for the synaptophysin level in the brains of the CKO mice, while the synaptophysin protein level was significantly decreased in the CKO × APP/PS1 mice (Fig. 4 d, e).

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Immunofluorescence staining showed a trend toward decreased synaptophysin levels in 4.5-month-old CKO mice and a significant reduction in synaptophysin levels in CKO × APP/PS1 mice (Fig. 4 g, h).

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