Endosomal sorting protein SNX4 limits synaptic vesicle docking and release.

Finally, the responding fluorescent puncta during AP stimulation as a ratio of the total fluorescent puncta during NH4, the percentage of active synapses, showed a trend toward fewer active synapses in SNX4 cKO neurons ( Figure 3g ).

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If this is the case, it should have been reflected as an increase in the evoked SypHy response in Fig 2c,d (which is borderline significant).

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